Piperonyl Butoxide is
a synergist used in a wide variety of insecticides and was developed in
1947 using naturally occurring safrole as the key raw ingredient.
Synergists are chemicals which, whilst lacking pesticidal properties of
their own, enhance the pesticidal properties of other active ingredients.
Piperonyl Butoxide is used in conjunction with insecticides such as pyrethrins,
pyrethroids, rotenone and carbamates.
OK..! so how does it work...well it inhibits the detoxification
of the pesticide by the insect. Some of an insect's metabolic enzymes, known
as Cytochrome P450, can detoxify an active ingredient before the desired
affect is achieved, and I am not going to go into the mechanism by which
it achieves that here. Adding piperonyl butoxide reduces the amount of active
ingredient required to achieve the affect we want and disrupts the enzyme
activity, thus indirectly it sort of makes the insecticide a bit more environmentally
friendly by reducing concentrations, something we all want.
The structure above may seem to
be different in some drawings due to rotation
about the single bonds.
Butacide; Butocide; Butyl carbitol 6-propylpiperonyl ether; ENT 14,250;
Pyrenone 606; 6-Propylpiperonyl butyl diethylene glycol ether; α-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene;
(butyl) diethylene glicol ether; Butylcarbityl (6-propylpiperonyl) ether;
Ethanol butoxide; FMC 5273; NCI-C02813; NIA 5273; PB; 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether;
3,4-Methylenedioxy-6-propylbenzyl n-butyl diethyleneglycol ether; 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole;
ether; Butoxide; FAC 5273; Nusyn-noxfish; Prentox; Pybuthrin; Pyrenon; Synpren-fish.
The oral LD50 for rats is 6150
mg/kg and for mice it is 3800 mg/kg, thus indicating that in itself it is
not too toxic, remember the bigger the number the less the toxicity.
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