Chlorophacinone is an
oil concentrate for impregnating bait material. Rozol is used also in production
of paraffin blocks, water bait, and tracking powder and is variously labeled
for use indoors and outdoors. Pests controlled: mice, rats, moles, muskrats,
voles and vampire bats. Can be used in food areas, schools, hospitals, nursery
homes and industrial plants. Does not require many feedings. It is an anticoagulant
rodenticide, a single dose of a 50 mg/kg bait killing Rattus norvegiaus
from the 5th day. It is normally incorporated as 50-250 mg/kg bait. It does
not induce "bait-shyness". In mammals it uncouples oxidative phospharylation
in addition to its anticoagulant action. This is the only rodenticide that
dissolves in oil. Controls warfarin resistant rodents.
concentrate, dust concentrate, baits, tracking powder, paraffin blocks,
pellets and ground spray. Concentrates available for mixing registered baits.
Variously labeled for indoor/outdoor use.
Chemical Name (IUPAC):
Chemical Formula: C23H15ClO3
100% chlorophacinone (Rat): Oral LD50 3.15 mg/kg (1
dose/21 days). 0.005% chlorophacinone form (Commensal rodents): LD50
63 g/kg. (Field mouse): generally 0.005%-0.0075% (varies by species/application).
Insoluble in water. It is also non-toxic to bees. DERMAL: LD50 = 200 mg/kg
(albino rabbit). A solution of 5 mg in 2 ml liquid paraffin applied to 100
cm2 of a rabbit's shaved skin caused only a slight reduction of prothrombin
Acute oral LD50: 430 mg/kg (red-winged blackbird): 100 mg/kg (mallard duck,
ring-necked pheasant). This product is toxic to fish and wildlife. Administration
of 15 daily doses of 2.25 mg to grey partridges produced no ill-effect.
Antidotal Information: If swallowed
or absorbed by humans, domestic animals or pets, this material may reduce
the clotting ability of the blood and cause bleeding. In that case, intravenous
and oral administration of Vitamin K, combined with blood transfusions are
indicated as in the case of hemorrhage caused by overdoses of bishydroxy
If there is uncertainty about the amount of bait ingested
or the general health of the patient, PHYTONADIONE (vitamin K1, Mephyton)
given orally protects against the anticoagulant effect of these rodenticides.
For adults, give 15-25 mg; for children under 12, give 5-10 mg. Alternatively,
a colloidal solution of phytonadione, Aquamephyton, may be given intramuscularly.
For adults, give 5-10 mg; for children under 12, give 1-5 mg.
specifically, is required. Neither vitamin K3 (menadione, Hykinone) nor
vitamin K4 (menadiol) is an antidote for these anticoagulants.
Sources: Cornell University
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