is a first generation anticoagulant of the warfarin type. Symptoms of overexposure
relate to failure of the blood clotting mechanism and include bleeding gums
and failure of blood clotting after skin wounds. After one exposure the
toxicity of coumatetralyl is relatively low, however if overexposure continues
over several days the product becomes more toxic. That is, the product must
be constantly present in the blood for more than 1 to 2 days in order to
be hi ghly toxic.
A single exposure, even though relatively large, may not produce toxic sypmtoms
as the compound is quite rapidly metabolised. Chronic: animal studies show
no evidence of carcinogenic or teratogenic effects.
LD50 Oral (ingestion)
- rat 16.5 mg/kg LD50 Dermal (skin contact) - rat 25-30 mg/kg These data
refer to the active constituent. The toxicity of the product is greater
after repeated exposure than in a single dose. Animal tests have shown coumatetralyl
not to have any carcinogenicor teratogenic potential.
occurs contact a doctor or Poisons Information Centre. Vitamin K1 (phytomenadione)
is antidotal. If swallowed, and if more than 15 minutes from a hospital,
induce vomiting, providing the patient is concious, preferably using a correct
emetic. If on skin, wash material off the skin with soap and water. If in
the eye, hold eye open and flood with water for at least 15 minutes and
see a doctor.
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