© Stuart M Bennett 2002


Chlorophacinone is an oil concentrate for impregnating bait material. Rozol is used also in production of paraffin blocks, water bait, and tracking powder and is variously labeled for use indoors and outdoors. Pests controlled: mice, rats, moles, muskrats, voles and vampire bats. Can be used in food areas, schools, hospitals, nursery homes and industrial plants. Does not require many feedings. It is an anticoagulant rodenticide, a single dose of a 50 mg/kg bait killing Rattus norvegiaus from the 5th day. It is normally incorporated as 50-250 mg/kg bait. It does not induce "bait-shyness". In mammals it uncouples oxidative phospharylation in addition to its anticoagulant action. This is the only rodenticide that dissolves in oil. Controls warfarin resistant rodents.

Formulation/s: Oil concentrate, dust concentrate, baits, tracking powder, paraffin blocks, pellets and ground spray. Concentrates available for mixing registered baits. Variously labeled for indoor/outdoor use.

Chemical Name (IUPAC): 2-[2-(4-chlorophenyl)-2-phenylacetyl]indan-1,3-dione.

Chemical Formula: C23H15ClO3

Chemical Structure:

LD50/LC50: 100% chlorophacinone (Rat): Oral LD50 3.15 mg/kg (1 dose/21 days). 0.005% chlorophacinone form (Commensal rodents): LD50 63 g/kg. (Field mouse): generally 0.005%-0.0075% (varies by species/application). Insoluble in water. It is also non-toxic to bees. DERMAL: LD50 = 200 mg/kg (albino rabbit). A solution of 5 mg in 2 ml liquid paraffin applied to 100 cm2 of a rabbit's shaved skin caused only a slight reduction of prothrombin rating.

Environmental: Acute oral LD50: 430 mg/kg (red-winged blackbird): 100 mg/kg (mallard duck, ring-necked pheasant). This product is toxic to fish and wildlife. Administration of 15 daily doses of 2.25 mg to grey partridges produced no ill-effect.

Antidotal Information: If swallowed or absorbed by humans, domestic animals or pets, this material may reduce the clotting ability of the blood and cause bleeding. In that case, intravenous and oral administration of Vitamin K, combined with blood transfusions are indicated as in the case of hemorrhage caused by overdoses of bishydroxy coumarin.

If there is uncertainty about the amount of bait ingested or the general health of the patient, PHYTONADIONE (vitamin K1, Mephyton) given orally protects against the anticoagulant effect of these rodenticides. For adults, give 15-25 mg; for children under 12, give 5-10 mg. Alternatively, a colloidal solution of phytonadione, Aquamephyton, may be given intramuscularly. For adults, give 5-10 mg; for children under 12, give 1-5 mg.

CAUTION: PHYTONADIONE, specifically, is required. Neither vitamin K3 (menadione, Hykinone) nor vitamin K4 (menadiol) is an antidote for these anticoagulants.

Sources: Cornell University


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